HOW CAN I USE THE RESULTS OF THE TEST FOR ENHANCING MY FERTILITY OR PRESERVING MY FUTURE FERTILITY?
Based on your risk estimation, we provide you personalised recommendations for your reproductive options, including:
- The recommendations to enhance your natural fertility
- The type of medical examination and tests needed
- The need for egg freezing and fertility preservation
- The options for assisted reproduction (like in vitro fertilization, IVF)
- The list of our partners providing you additional medical counseling
I HAVE A HIGH GENETIC RISK FOR EARLY MENOPAUSE, DOES THIS MEAN THAT I WILL INEVITABLY HAVE EARLY MENOPAUSE?
No, it just means that you have a higher (genetic) risk of early menopause.
I HAVE A LOW GENETIC RISK FOR EARLY MENOPAUSE, DOES THIS MEAN I DO NOT HAVE TO WORRY ABOUT EARLY MENOPAUSE?
According to different estimates, genetic variation determines about 50-80% of the variation in menopausal timing, and currently our risk estimates are calculated based on only genetic data. There are also certain lifestyle factors, such as smoking, that can lead to early menopause. Early menopause can also occur as a result of some disease, or after chemo- or radiotherapy.
WHAT ARE THE OTHER FACTORS BESIDES GENETICS THAT INFLUENCE AGE AT MENOPAUSE?
According to different estimates, genetic variation determines about 50-80% of the variation in menopausal timing. Smoking is one of the most important lifestyle factors influencing reproductive aging. Early menopause can also occur as a result of some disease, or after chemo- or radiotherapy.
HOW MANY AND WHICH GENES ARE ANALYSED WITH THIS TEST?
Our test uses polygenic risk scores for assessing the risk of early menopause. Polygenic risk scores summarize the effect of many genetic variants (usually single nucleotide variations in your DNA). These variants may be associated with a specific gene, but may also be located between genes or in a regulatory area. Currently, our test summarizes the effects of about 800 genetic variants. It has been shown that the genetic variants affecting menopausal aging are often associated with repairing DNA damage or immune response (https://www.ncbi.nlm.nih.gov/pubmed/26414677).
HAVE ANY STUDIES BEEN PUBLISHED THAT SUPPORT THE ASSOCIATION BETWEEN GENETIC RISK AND MENOPAUSAL AGE?
The effect genetic variants have on menopausal age has been analysed in multiple studies. The latest was published by the ReproGen consortium in 2015 (https://www.ncbi.nlm.nih.gov/pubmed/26414677). In this study, the genetic data of 70,000 women was used to evaluate the effect of more than 2 million genetic markers on menopausal timing. Our algorithm uses data from this study to summarize the effects of genetic markers and generate an individual risk score.
HOW ACCURATE IS THE TEST?
At the moment we use an algorithm that calculates the risk based purely on genetic data and the accuracy of the estimates is 65%.
WHO WILL HAVE ACCESS TO/ANALYSE MY DATA?
Your data will be coded, processed, analysed and stored by Tervisetehnoloogiate Arenduskeskus AS.
WHEN DO I GET THE RESULTS?
Processing your data will take approximately 2-4 weeks. Yet the actual time of individual report delivery can be up to 3 month, depending on genotyping lab workload.
HOW LONG WILL YOU STORE THE SAMPLES/DATA?
The samples will be used for DNA extraction which is then used for genotyping. As we aim to continuously improve our algorithms and provide our clients with the most accurate predictions, we will create a database to store your genetic data. This way, whenever we come up with a new and better risk prediction model, we can update your risk profile without the need for another sample.
CAN I REQUEST TERVISETEHNOLOOGIATE ARENDUSKESKUS AS TO DESTROY ALL MY PESONAL AND GENOME DATA?
Of course, by request, all personal and genome data will be completely destroyed after the test report is delivered to the client.
WHAT IF MY DNA HAS ALREADY BEEN GENOTYPED GENOME-WIDE (EITHER USING ARRAY OR SEQUENCING)?
If you already have information about your DNA either from array genotyping or sequencing and you want to know your genetic risk for early menopause, please contact us ().